Blar i forfatter "Sørbye, Sveinung Wergeland"

Viser treff 1-20 av 40

    • 5-type HPV mRNA versus 14-type HPV DNA test: test performance, over-diagnosis and overtreatment in triage of women with minor cervical lesions 

      Westre, Bjørn; Giske, Anita; Guttormsen, Hilde; Sørbye, Sveinung Wergeland; Skjeldestad, Finn Egil (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-06-07)

    • Dynamics of the IL-33/ST2 network in the progression of human colorectal adenoma to sporadic colorectal cancer 

      Guanglin, Cui; Qi, Haili; Gundersen, Mona Dixon; Yang, Hang; Christiansen, Ingrid B; Sørbye, Sveinung Wergeland; Goll, Rasmus; Florholmen, Jon (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-10-17)
      Most sporadic colorectal cancers (CRCs) develop from preformed adenomas. Cytokines are involved in the transition from adenoma to CRC. Interleukin-33 (IL-33) is a newly discovered proinflammatory cytokine belonging to the IL-1 cytokine family and involved in the development of chronic inflammation and cancer. The aim of this study was to evaluate the dynamics of the IL-33/ST2 axis during the sequence ...

    • Fibroblast growth factor 2 orchestrates angiogenic networking in non-GIST STS patients 

      Kilvær, Thomas Karsten; Valkov, Andrey Yurjevich; Sørbye, Sveinung Wergeland; Smeland, Eivind; Bremnes, Roy M.; Busund, Lill-Tove; Dønnem, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Non-gastrointestinal stromal tumor soft-tissue sarcomas (non-GIST STSs) constitute a heterogeneous group of tumors with poor prognosis. Fibroblast growth factor 2 (FGF2) and fibroblast growth factor receptor-1 (FGFR-1), in close interplay with platelet-derived growth factor-B (PDGF-B) and vascular endothelial growth factor receptor-3 (VEGFR-3), are strongly involved in angiogenesis. This study ...

    • Fibrosis Mediators in the Colonic Mucosa of Acute and Healed Ulcerative Colitis 

      Gundersen, Mona Dixon; Goll, Rasmus; Fenton, Christopher Graham; Anderssen, Endre; Sørbye, Sveinung Wergeland; Florholmen, Jon; Paulssen, Ruth H (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-03)
      <i>OBJECTIVES</i>: A healed intestinal mucosa is the aim of therapy in acute ulcerative colitis (UC). Disruption of mucosal wound healing may lead to severe complications including intestinal fibrosis. This study examined mucosal gene expression in the healing process of acute UC with a special focus on known mediators of fibrosis.<p> <p><i>METHODS</i>: Endoscopic biopsies from patients with ...

    • High expression of CD20+ lymphocytes in soft tissue sarcomas is a positive prognostic indicator 

      Sørbye, Sveinung Wergeland; Kilvær, Thomas Karsten; Valkov, Andrey Yurjevich; Dønnem, Tom; Smeland, Eivind; Al-Shibli, Khalid Ibrahim; Bremnes, Roy M.; Busund, Lill-Tove (Journal article; Tidsskriftartikkel, 2012)
      The immune status is important in cancer patients. Tissue microarrays from 249 patients with soft tissue sarcomas were constructed. Immunohistochemistry was used to evaluate the CD3+, CD4+, CD8+, CD20+ and CD45+ lymphocytes in tumors. High density of CD20+ lymphocytes is an independent positive prognostic indicator for these patients.

    • HPV E6/E7 mRNA Testing Is More Specific than Cytology in Post-Colposcopy Follow-Up of Women with Negative Cervical Biopsy 

      Sørbye, Sveinung Wergeland; Arbyn, Marc; Fismen, Silje; Gutteberg, Tore Jarl; Mortensen, Elin Synnøve (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      In Norway, women with negative or low-grade cervical biopsies (normal/CIN1) are followed up after six months in order to decide on further follow-up or recall for screening at three-year intervals. A high specificity and positive predictive value (PPV) of the triage test is important to avoid unnecessary diagnostic and therapeutic procedures whereas a low risk of high-grade disease among triage ...

    • HPV mRNA is more specific than HPV DNA in triage of women with minor cervical lesions 

      Sørbye, Sveinung Wergeland; Fismen, Silje; Gutteberg, Tore Jarl; Mortensen, Elin Synnøve; Skjeldestad, Finn Egil (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-11-18)
      311 women were scheduled for triage of minor cervical lesions (ASC-US / LSIL). 30 women (9.6%) had ASC-H/HSIL cytology at triage and 281 women (90.4%) had ASC-US/LSIL or normal cytology. The HPV DNA test was positive in 92 (32.7%) of 281 instances, and 37 (13.2%) were mRNA positive. Of the 132 women with repeated ASC-US/LSIL, we received biopsies from 97.0% (65/67) of the DNA-positive and 92.9% ...

    • HPV mRNA test in primry screening of women 20-34 years 

      Sørbye, Sveinung Wergeland; Fismen, Silje; Gutteberg, Tore Jarl; Mortensen, Elin Synnøve; Skjeldestad, Finn Egil (Conference object; Konferansebidrag, 2011)

    • HPV mRNA test in women with minor cervical lesions : experience of the University Hospital of North Norway 

      Sørbye, Sveinung Wergeland; Fismen, Silje; Gutteberg, Tore Jarl; Mortensen, Elin (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)
      In the Norwegian Cervical Cancer Screening Programme tests for detection of human papillomavirus (HPV) are used to triage women with minor cytological cervical lesions. The material in this study comprises samples from 1798 women in the period 2006–2008. The HPV test was performed according to the guidelines of the Norwegian Cancer Registry. The HPV mRNA test (PreTect HPV-Proofer) detects and types ...

    • HPV mRNA testing in triage of women with ASC-US cytology may reduce the time for CIN2+ diagnosis compared with repeat cytology. 

      Sørbye, Sveinung Wergeland; Fismen, Silje; Gutteberg, Tore Jarl; Mortensen, Elin Synnøve; Skjeldestad, Finn Egil (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Background: In delayed HPV triage women with atypical squamous cells of uncertain significance (ASC-US) cytology are retested after 6-12 months in order to decide whether they should be referred for colposcopy, further follow-up cytology or routine screening in three years. Triage using a specific HPV E6/E7 mRNA test may reduce referrals for colposcopy of women with ASC-US cytology compared to HPV ...

    • HPV mRNA testing is more specific than HPV DNA testing in triage of women with minor cervial lesions 

      Sørbye, Sveinung Wergeland; Fismen, Silje; Gutteberg, Tore Jarl; Mortensen, Elin; Skjeldestad, Finn Egil (Conference object; Konferansebidrag, 2013)
      In Norway, repeat cytology and HPV testing is used in delayed triage of women with minor cytological lesions. Repeat cytology, HPV DNA testing (Roche Cobas 4800), and HPV mRNA testing (NorChip PreTect HPV-Proofer) were used to follow up 575 women aged 25–69 years with ASCUS / LSIL in primary screening. A total of 206 women (35.8%) were DNA+ and 107 (18.6%) were mRNA+. Repeated ASC-US / LSIL was found ...

    • HPV types in cervical cancer tissue in South Africa: A head-to-head comparison by mRNA and DNA tests 

      Rad, Amir; Sørbye, Sveinung Wergeland; Dreyer, Greta; Hovland, Siri; Falang, Bente Marie; Louw, Melanie; Skjeldestad, Finn Egil (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-01)
      <p>Accurate identification of human papillomavirus (HPV)-types in cervical cancer tissue may be important for tailoring tests for primary screening and types to be included in a vaccine. The aim of this study was to compare test-performance of a 45-type HPV deoxyribonucleic acid (DNA)-test with a 9-type HPV messenger ribonucleic acid (mRNA)-test in cervical cancer tissues. <p>In a case-series design ...

    • HPV-testing og livmorhalskreft 

      Sørbye, Sveinung Wergeland (Journal article; Tidsskriftartikkel, 2014)
      Noen typer kreft er forårsaket av virusinfeksjoner. På verdensbasis er det beregnet at 15 % av all kreft skyldes virus. Humant papillomavirus (HPV) er årsak til 5 % av kreft, og dette viruset er påvist i kreft i blant annet livmorhals, vulva, vagina, penis, anus, tonsiller og tungebasis.

    • Independent and Tissue-Specific Prognostic Impact of miR-126 in Nonsmall Cell Lung Cancer 

      Dønnem, Tom; Lønvik, Kenneth; Eklo, Katrine; Berg, Thomas; Sørbye, Sveinung Wergeland; Al-Shibli, Khalid Ibrahim; Al-Saad, Samer; Andersen, Sigve; Stenvold, Helge; Bremnes, Roy M.; Busund, Lill-Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Angiogenesis is pivotal in tumor development. Vascular endothelial growth factor-A (VEGF-A) is considered one of the most important angiogenic factors, but lately several microRNAs (miRs) have been associated with vascular development. miR-126 has been related to tumor angiogenesis and in the regulation of VEGF-A. The authors aimed to investigate the prognostic impact of miR-126 and its co-expression ...

    • Loss of interleukin 33 expression in colonic crypts- a potential marker for disease remission in ulcerative colitis 

      Gundersen, Mona Dixon; Goll, Rasmus; Hol, Johanna; Olsen, Trine; Rismo, Renathe; Sørbye, Sveinung Wergeland; Sundnes, Olav; Haraldsen, Guttorm; Florholmen, Jon (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-17)
      Interleukin 33 (IL-33) is a cytokine preferentially elevated in acute ulcerative colitis (UC), inferring a role in its pathogenesis. The role of IL-33 in intestinal inflammation is incompletely understood, with both pro-inflammatory and regulatory properties described. There are also conflicting reports on cellular sources and subcellular location of IL-33 in the colonic mucosa, justifying a closer ...

    • Ny generasjon HPV-tester på vent 

      Sørbye, Sveinung Wergeland; Gutteberg, Tore Jarl; Vintermyr, Olav Karsten (Chronicle; Kronikk, 2010-09-18)
      Ny forskning viser at gentester for humant papillomvirus (HPV) siler ut de behandlingstrengende i langt større grad enn celleprøver. Samtidig er det grunn til å tro at mRNA-tester bør velges fremfor DNA-tester.

    • Patolog slår tilbake mot gynekologer 

      Sørbye, Sveinung Wergeland (Chronicle; Kronikk, 2011-12-12)
      Antallet tilfeller av livmorhalskreft er stabilt i Norge, men har gått ned ved de fem sykehusene som har brukt den RNA-baserte HPV-testen, hevder patolog Sveinung Wergeland Sørbye.

    • Primary cervical cancer screening with an HPV mRNA test: a prospective cohort study 

      Sørbye, Sveinung Wergeland; Fismen, Silje; Gutteberg, Tore Jarl; Mortensen, Elin Synnøve; Skjeldestad, Finn Egil (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-08-11)
      <b>Objectives</b> To assess the performance of a 5-type human papillomavirus (HPV) messenger RNA (mRNA) test in primary screening within the framework of the Norwegian population-based screening programme. <br> <b>Design</b> Nationwide register-based cohort study. <br> <b>Setting</b> In 2003–2004, general practitioners and gynaecologists recruited 18 852 women for participation in a primary ...

    • Profiling of VEGFs and VEGFRs as prognostic factors in soft tissue sarcoma: VEGFR-3 is an independent predictor of poor prognosis 

      Smeland, E; Kilvær, Thomas Karsten; Valkov, Andrey Yurjevich; Sørbye, Sveinung Wergeland; Bremnes, Roy M.; Busund, Lill-Tove Rasmussen; Dønnem, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)

    • The prognostic impact of Akt isoforms, PI3K and PTEN related to female steroid hormone receptors in soft tissue sarcomas 

      Valkov, Andrey Yurjevich; Kilvær, Thomas Karsten; Sørbye, Sveinung Wergeland; Dønnem, Tom; Smeland, Eivind; Bremnes, Roy M.; Busund, Lill-Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      The PI3K/Akt pathway is involved in cellular survival pathways by inhibiting apoptotic processes and stimulating cell growth and proliferation. Its negative prognostic value has been proven in many types of cancer. In soft tissue sarcomas, the expression profiles of the PI3K/Akt pathway components are poorly defined and their significance uncertain. We aimed to investigate the prognostic impact of ...